11/19/2023 0 Comments Plexiform layersThe rate of change in the average GCIPL thickness was significantly higher in progressors (-1.05☐.98 μm/year for mild glaucoma and -0.66☐.30 μm/year for moderate to advanced glaucoma) than in nonprogressors (-0.47☐.54 μm/year for mild glaucoma and -0.31☐.50 μm/year for moderate to advanced glaucoma), regardless of glaucoma severity (P < 0.05). Seventy-six eyes (38.8%) and 43 eyes (21.9%) demonstrated progressive GCIPL and RNFL thinning, respectively, and 48 eyes (24.5%) were classified as progressors by reference standard. Progressive GCIPL and RNFL thinning assessed by OCT GPA. Visual field survival estimates in eyes with and without progressive GCIPL and RNFL thinning were evaluated by Kaplan-Meier survival analysis and compared with the log-rank test. Ganglion cell-inner plexiform layer and RNFL thinning rates were compared between progressors and nonprogressors. Glaucomatous eyes were classified into mild (117 eyes) or moderate to advanced (79 eyes) groups based on VF defects. The reference standard of glaucoma progression was determined by visual field (VF) progression. Macular GCIPL and peripapillary RNFL thicknesses were measured by Cirrus HD-OCT (Zeiss, Dublin, CA), and progressive GCIPL and RNFL thinning were assessed by GPA. Let us know how this access is important for you.To examine the performance of Guided Progression Analysis (GPA Carl Zeiss Meditec, Dublin, CA) in spectral-domain optical coherence tomography (OCT) in detecting progressive thinning of ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in glaucoma.Ī total of 196 eyes of 123 primary open-angle glaucoma patients (mean follow-up, 5.0 years). Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Translational relevanceThere is no evidence for preferential thinning of the macular IPL in glaucoma compared with GCL based on currently available SD-OCT-imaging technology. Preferential thinning of the macular IPL, compared with GCL, could not be detected in this study regardless of glaucoma stage. ConclusionsEthnicity and distance from the fovea are the main determinants of IPL thickness in the central macula. The results were similar when only eyes with mean deviation greater than -6 dB were analyzed. Diagnosis of glaucoma was not associated with thinner IPL regardless of eccentricity after accounting for age and ethnicity. ResultsBeing located at 4.5° eccentricity predicted thicker IPL compared with 1.5° eccentricity ( P < 0.001) in multivariable models in healthy subjects, whereas older age ( P = 0.001) and Asian ethnicity ( P = 0.021) were associated with thinner IPL. Linear mixed models were used to determine predictive parameters for IPL thickness in healthy subjects and to explore the influence of diagnosis of glaucoma on IPL thickness taking into account the effect of GCL thickness and other covariates. The central 24 superpixels were categorized into three levels of eccentricity (∼1.5°, 4.5°, and 7.5° from the foveal center). MethodsNinety-nine glaucomatous eyes and 66 healthy eyes (165 subjects) underwent macular spectral-domain optical coherence tomography (SD-OCT) imaging and GCL and IPL were segmented creating 8 × 8 arrays of 3° × 3° superpixels. PurposeTo explore factors influencing the inner plexiform layer (IPL) in healthy subjects and to test the hypothesis that IPL thickness is preferentially decreased in glaucoma as compared with ganglion cell layer (GCL) thickness.
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